When an assassin's bullet confines him to a wheelchair for life ending his career as Chief of Detectives, Robert T. Ironside becomes a consultant to the police department. Detective Sergeant Ed Brown and policewoman Eve Whitfield join with him to crack varied and fascinating cases. Ex-con Mark Sanger is employed by the chief as home help but eventually becomes a fully fledged member of the team also. Officer Whitfield leaves after 4 years service, and is replaced by Officer Fran Belding.
Raymond Burr
as Robert Ironside
Don Galloway
as Ed Brown
Don Mitchell
as Mark Sanger
Barbara Anderson
as Eve Whitfield
Elizabeth Baur
as Fran Belding