Blossom Russo is a highly intelligent and spunky teenager. The youngest of three, she lives with her divorced musician father, Nick, eldest brother and recovering substance abuser Anthony, and decidedly not-so-bright middle brother Joey. Along for the ride is Blossom's ditzy best friend, Six, who sometimes shows flashes of great perception.
Mayim Bialik
as Blossom Russo
Joey Lawrence
as Joey Russo
Michael Stoyanov
as Anthony Russo
Jenna von Oy
as Six LeMuere
Ted Wass
as Nick Russo
Finola Hughes
as Carol Russo
Samaria Graham
as Shelly Lewis Russo
Courtney Chase
as Kennedy Russo