Focuses on a group of toddlers, most prominently Tommy, Chuckie, Phil, Lil, and Angelica, and their day-to-day lives, usually involving common life experiences that become adventures in the babies' imaginations. Adults in the series are almost always unaware of what the children are up to; however, this only provides more room for the babies to explore and discover their surroundings.
Elizabeth Daily
as Tommy Pickles (voice)
Kath Soucie
as Phil DeVille / Lil DeVille (voice)
Cheryl Chase
as Angelica Pickles (voice)
Dionne Quan
as Kimi Finster (voice)
Tara Strong
as Dil Pickles (voice)
Joe Alaskey
as Grandpa Lou Pickles (voice)
Melanie Chartoff
as Didi Pickles (voice)
Tress MacNeille
as Charlotte Pickles (voice)
Jack Riley
as Stu Pickles (voice)
Cree Summer
as Susie Carmichael (voice)
Nancy Cartwright
as Chuckie Finster (voice)
