A leukemia patient attempts to end a 20-year feud with her sister to get her bone marrow.
Meryl Streep
as Lee Wakefield Lacker
Diane Keaton
as Bessie Wakefield
Leonardo DiCaprio
as Hank Lacker
Robert De Niro
as Wallace "Wally" Carter
Hume Cronyn
as Marvin Wakefield
Gwen Verdon
as Ruth Wakefield
Hal Scardino
as Charlie Lacker
Dan Hedaya
as Robert "Bob" Carter
Margo Martindale
as Charlotte Samit
Cynthia Nixon
as Retirement Home Director
Kelly Ripa
as Coral
John Callahan
as Lance