Mollie and James are together and raising a family, which now consists of an older Mikey and his baby sister, Julie. Tension between the siblings arises, and as well with Mollie and James when Mollie's brother Stuart moves in. Mikey is also learning how to use the toilet for the first time.
Kirstie Alley
as Mollie Ubriacco
John Travolta
as James Ubriacco
Bruce Willis
as Mikey (voice)
Roseanne Barr
as Julie (voice)
Gilbert Gottfried
as Joey
Damon Wayans
as Eddie (voice)
Mel Brooks
as Mr. Toilet Man (voice)
Olympia Dukakis
as Rosie
Elias Koteas
as Stuart
Twink Caplan
as Rona
Lorne Sussman
as Mikey
Megan Milner
as Julie
