French nuclear tests irradiate an iguana into a giant monster that viciously attacks freighter ships in the Pacific Ocean. A team of experts, including Niko Tatopoulos, conclude that the oversized reptile is the culprit. Before long, the giant lizard is loose in Manhattan as the US military races to destroy the monster before it reproduces and it's spawn takes over the world.
Matthew Broderick
as Dr. Niko Tatopoulos
Jean Reno
as Philippe Roaché
Maria Pitillo
as Audrey Timmonds
Hank Azaria
as Victor 'Animal' Palotti
Kevin Dunn
as Colonel Hicks
Michael Lerner
as Mayor Ebert
Harry Shearer
as Charles Caiman
Arabella Field
as Lucy Palotti
Vicki Lewis
as Dr. Elsie Chapman
Doug Savant
as Sergeant O'Neal
Malcolm Danare
as Dr. Mendel Craven
Lorry Goldman
as Gene, Mayor's Aide
