College "frenemies" Lauren and Katie move in together after losing a relationship and rent control, respectively. Sharing Katie's late grandmother's apartment in New York City, the girls bicker with each other until one fateful night, when Katie's noisy bedroom activities make Lauren barge in and discover a dirty little secret. This revelation brings them closer together, and Lauren (the brains) and Katie (the talent) concoct a wildly successful business venture. As profits swell, the girls reevaluate their hopes and dreams and realize that just because someone pees in your hair in college doesn't mean she won't be your best friend 10 years later.
Ari Graynor
as Katie Steel
Lauren Miller Rogen
as Lauren Powell
Justin Long
as Jesse
Mark Webber
as Sean
Mimi Rogers
as Adele
Don McManus
as Scott
Nia Vardalos
as Rachel Rodman
Seth Rogen
as Jerry
Veronika Dash
as Bridgette
James Wolk
as Charlie
Sugar Lyn Beard
as Krissy
Ken Marino
as Harold
