William Shatner plays two roles: cowboy Johnny Moon and his ruthless Indian twin brother, Notah. Notah likes peyote and gets the crazy idea that he's the Comanche messiah sent to lead the Comanche nation against the white man but more specifically the dusty desert town of Rio Hondo. Moon, estranged from his brother, decides to stop Notah either by words or by bullets.
Joseph Cotten
as Sheriff Logan
William Shatner
as Johnny Moon / Notah
Rosanna Yanni
as Kelly
Perla Cristal
as White Fawn
Mariano Vidal Molina
as General Garcia
Luis Prendes
as Grimes
Barta Barri
as Major Bolker
Víctor Israel
as Carter
José Terrón
as Comanche / Townsman
Soledad Miranda
as India
Diana Lorys
as