Cousins, Bo and Luke Duke, with the help of their eye-catching cousin, Daisy and moonshine-running Uncle Jesse, try and save the family farm from being destroyed by Hazzard County's corrupt commissioner, Boss Hogg. Their efforts constantly find the 'Duke Boys' eluding authorities in 'The General Lee', their 1969 orange Dodge Charger that keeps them one step ahead of the dimwitted antics of the small southern town's Sheriff, Roscoe P. Coltrane.
Johnny Knoxville
as Luke Duke
Seann William Scott
as Bo Duke
Jessica Simpson
as Daisy Duke
Willie Nelson
as Uncle Jesse Duke
Burt Reynolds
as Jefferson Davis 'Boss' Hogg
M.C. Gainey
as Sheriff Rosco P. Coltrane
James Roday Rodriguez
as Billy Prickett
David Koechner
as Cooter Davenport
Michael Weston
as Deputy Enos Strate
Nikki Griffin
as Katie Johnson
Alice Greczyn
as Laurie Pullman
Joe Don Baker
as Governor Jim Applewhite