As Emily struggles to fit in at home and at school, she discovers a small red puppy who is destined to become her best friend. When Clifford magically undergoes one heck of a growth spurt, becomes a gigantic dog and attracts the attention of a genetics company, Emily and her Uncle Casey have to fight the forces of greed as they go on the run across New York City. Along the way, Clifford affects the lives of everyone around him and teaches Emily and her uncle the true meaning of acceptance and unconditional love.
Darby Camp
as Emily Elizabeth
Jack Whitehall
as Casey
Izaac Wang
as Owen Yu
John Cleese
as Mr. Bridwell
Tony Hale
as Zack Tieran
David Alan Grier
as Packard
Paul RodrÃguez
as Sanchez
Horatio Sanz
as Raul
Sienna Guillory
as Maggie
Rosie Perez
as Lucille
Kenan Thompson
as Vet
Jessica Keenan Wynn
as Colette
