Three stories about the world of opioids collide: a drug trafficker arranges a multi-cartel Fentanyl smuggling operation between Canada and the U.S., an architect recovering from an OxyContin addiction tracks down the truth behind her son's involvement with narcotics, and a university professor battles unexpected revelations about his research employer, a drug company with deep government influence bringing a new "non-addictive" painkiller to market.
Gary Oldman
as Dr. Tyrone Brower
Armie Hammer
as Jake Kelly
Evangeline Lilly
as Claire Reimann
Greg Kinnear
as Dean Talbot
Michelle Rodriguez
as Supervisor Garrett
Luke Evans
as Dr. Bill Simons
Lily-Rose Depp
as Emmie Kelly
Guy Nadon
as Mother
Veronica Ferres
as Dr. Meg Holmes
Kid Cudi
as Ben Walker
Mia Kirshner
as Susan
Michael Aronov
as Minas
