Eight years after the third film, the OSS has become the world's top spy agency, while the Spy Kids department has since become defunct. A retired spy Marissa is thrown back into the action along with her stepchildren when a maniacal Timekeeper attempts to take over the world. In order to save the world, Rebecca and Cecil must team up with their hated stepmother. Carmen and Juni have since also grown up and will provide gadgets to them.
Jessica Alba
as Marissa Wilson
Joel McHale
as Wilbur Wilson
Rowan Blanchard
as Rebecca Wilson
Mason Cook
as Cecil Wilson
Jeremy Piven
as Danger D'Amo / Tick Tock / Time Keeper
Alexa PenaVega
as Carmen Cortez
Daryl Sabara
as Juni Cortez
Danny Trejo
as Uncle Machete
Belle Solorzano
as Spy Baby
Genny Solorzano
as Spy Baby
Ricky Gervais
as Voice of Argonaut
Elmo
as Argonaut
