The seemingly invincible Spider-Man goes up against an all-new crop of villains—including the shape-shifting Sandman. While Spider-Man’s superpowers are altered by an alien organism, his alter ego, Peter Parker, deals with nemesis Eddie Brock and also gets caught up in a love triangle.
Tobey Maguire
as Spider-Man / Peter Parker
Kirsten Dunst
as Mary Jane Watson
James Franco
as New Goblin / Harry Osborn
Thomas Haden Church
as Sandman / Flint Marko
Topher Grace
as Venom / Eddie Brock
Bryce Dallas Howard
as Gwen Stacy
Rosemary Harris
as May Parker
J.K. Simmons
as J. Jonah Jameson
James Cromwell
as Captain Stacey
Dylan Baker
as Dr. Curt Connors
Theresa Russell
as Emma Marko
Bill Nunn
as Joseph 'Robbie' Robertson
