Smith, a mob informer hiding out with the Witness Protection Program, decides to make a break for it and hide out in the Arizona desert. The Feds catch up with him and rescue him just before a group of hitmen can manage to silence him for good. In the course of getting Smith away from the mafia thugs, the pair of agents assigned to protect him turn onto an abandoned stretch of highway nicknamed 'Route 666' after the mysterious death of a prison chain gang. As the three continue on their way, they soon discover just what happened to the chain gang, and how the highway earned its name.
Lou Diamond Phillips
as Jack La Roca
Lori Petty
as Steph
Steven Williams
as Rabbit aka Fred
L.Q. Jones
as Sheriff Bob Conaway
Dale Midkiff
as P.T.
Mercedes Colon
as Mary
Rob Roy Fitzgerald
as Joe
Adam Vernier
as Deputy Gil Conaway
Chester E. Tripp III
as Deputy Tim Conaway
Alex McArthur
as Nick
Dick Miller
as Bartender
Anne Lockhart
as Radio Dispatcher
