Based partially on the story of Bonnie and Clyde, Eddie Taylor is an ex-convict who cannot get a break after being released from prison. When he is framed for murder, Taylor is forced to flee with his wife Joan Graham and baby. While escaping prison after being sentenced to death, Taylor becomes a real murderer, condemning himself and Joan to a life of crime and death on the road.
Sylvia Sidney
as Joan Graham
Henry Fonda
as Eddie Taylor
Barton MacLane
as Stephen Whitney
Jean Dixon
as Bonnie Graham
William Gargan
as Father Dolan
Jerome Cowan
as Dr. Hill
Charles 'Chic' Sale
as Ethan
Margaret Hamilton
as Hester
Warren Hymer
as Buggsy
Guinn "Big Boy" Williams
as Rogers
John Wray
as Warden Wheeler
Walter De Palma
as Monk Mendall (uncredited)