Oregon, 1851. Hermann Kermit Warm, a chemist and aspiring gold prospector, keeps a profitable secret that the Commodore wants to know, so he sends the Sisters brothers, two notorious assassins, to capture him on his way to California.
John C. Reilly
as Eli Sisters
Joaquin Phoenix
as Charlie Sisters
Jake Gyllenhaal
as John Morris
Riz Ahmed
as Hermann Kermit Warm
Rebecca Root
as Mayfield
Allison Tolman
as Girl Mayfield Saloon
Rutger Hauer
as The Commodore
Carol Kane
as Mrs Sisters
Patrice Cossonneau
as Blount
Zac Abbott
as Blount Guy Dying
David Gasman
as Relay Owner
Philip Rosch
as Storekeeper Pioneer Town 2
