Christmas Eve in New York, and the lonely divorced publisher, Rose Collins, needs a miracle to improve the health of her mother, interned in a hospital with Alzheimers. She feels sorry for another patient and meets his visitor. Meanwhile, Nina Vasquez breaks her engagement with her beloved fiancé Mike due to his suffocating jealousy, but misses him. Mike is stalked by a stranger, bartender Artie Venzuela. The poor Jules arranges to spend Christmas Eve in the hospital, where he spent the best Christmas of his life when he was a teenager. The lives of some of these characters cross with others along the night.
Susan Sarandon
as Rose Collins
Paul Walker
as Mike Riley
Penélope Cruz
as Nina Vasquez
Alan Arkin
as Artie
Marcus Thomas
as Jules Calvert
Sonny Marinelli
as Dennis
Daniel Sunjata
as Marco
Chazz Palminteri
as Arizona
Robin Williams
as Charlie Boyd / The Priest
Rob Daly
as Paul
John Doman
as Dr. Baron
Billy Porter
as Randy
