When Phil and Debbie Winslow relocate from their native Kansas to the sunny climes of Orange County, their big-hearted, havoc-wreaking Great Dane gets a taste of the dog's life, California-style.
Owen Wilson
as Marmaduke (voice)
Emma Stone
as Mazie (voice)
George Lopez
as Carlos (voice)
Caroline Sunshine
as Barbara Winslow
Finley Jacobsen
as Brian Winslow
Steve Coogan
as Raisin (voice)
Christopher Mintz-Plasse
as Giuseppe (voice)
Fergie
as Jezebel (voice)
Kiefer Sutherland
as Bosco (voice)
Lee Pace
as Phil Winslow
Judy Greer
as Debbie Winslow
Damon Wayans Jr.
as Thunder (voice)