Retroville becomes ground zero for a meteor engraved with a mysterious alien message, which only the best and brightest(naturally, Jimmy) can translate. When he finally figures the message out, he and his friends are teleported into deep space and are forced to become contestants on an intergalactic reality game show, where the losers have their home planets destroyed.
Debi Derryberry
as Jimmy Neutron / Alien Actress / Alien Woman (voice)
Rob Paulsen
as Carl Wheezer/Mr. Wheezer/Mrs. Wheezer/Test Pilot/Announcer (voice)
Jeffrey Garcia
as Sheen Estevez / Army Guard (voice)
Frank Welker
as Goddard (voice)
Carolyn Lawrence
as Cindy Vortex (voice)
Crystal Scales
as Libby Folfax (voice)
Tim Allen
as Meldar Prime (voice)
Alyssa Milano
as April (voice)
Carlos Alazraqui
as Sr. Estevez (voice)
Jeff Bennett
as Gorlock #2 / Brain #1 (voice)
Megan Cavanagh
as Judy Neutron / Mrs. Vortex (voice)
Jim Cummings
as Brain #2 / Mayor Quadar (voice)
