In a Spain consumed by ambition and power, the future of an empire depends of the mind state of a single woman.
Rodolfo Sancho
as Fernando II de Aragón
Irene Escolar
as Juana I de Castilla
Raúl Mérida
as Felipe I de Castilla
Eusebio Poncela
as Cardenal Cisneros
Ramón Madaula
as Gonzalo Chacón
Jordi Díaz
as Andrés de Cabrera
Fernando Guillén Cuervo
as Gutierre Gómez de Fuensalida
Úrsula Corberó
as Margarita de Austria
Silvia Alonso
as Germana de Foix
Jose Coronado
as Maximiliano I de Habsburgo
Pedro Mari Sánchez
as Pedro Manrique de Lara y Sandoval
Ramón Barea
as Fadrique Álvarez de Toledo y Enríquez