Upon learning that their mother has been lying to them for years about their allegedly deceased father, two fraternal twin brothers hit the road in order to find him.
Owen Wilson
as Kyle Reynolds
Ed Helms
as Peter Reynolds
J.K. Simmons
as Ronald Hunt
Katt Williams
as Hitchhiker
Terry Bradshaw
as Terry Bradshaw
Ving Rhames
as Rod Hamilton
Christopher Walken
as Dr. Walter Tinkler
Glenn Close
as Helen Baxter
Katie Aselton
as Sarah O'Callaghan
Retta
as Annie
Harry Shearer
as Gene
June Squibb
as Mrs. Hunt
