FBI agent Neville Flynn boards a flight from Honolulu, Hawaii to Los Angeles, escorting a key witness to testify against a mob boss at an upcoming trial. An on-board assassin releases a crate full of hundreds of deadly venomous snakes in an attempt to eliminate the witness. Flynn and a host of frightened passengers and crew must band together to survive the slithery threat.
Samuel L. Jackson
as Neville Flynn
Julianna Margulies
as Claire Miller
Nathan Phillips
as Sean Jones
Kenan Thompson
as Troy
Rachel Blanchard
as Mercedes
Flex Alexander
as Three G's
Keith Dallas
as Big Leroy
Sunny Mabrey
as Tiffany
Lin Shaye
as Grace
Elsa Pataky
as Maria
Bruce James
as Ken
Casey Dubois
as Curtis
