A sorority moves in next door to the home of Mac and Kelly Radner who have a young child. The Radner's enlist their former nemeses from the fraternity to help battle the raucous sisters.
Seth Rogen
as Mac Radner
Zac Efron
as Teddy Sanders
Rose Byrne
as Kelly Radner
Chloë Grace Moretz
as Shelby
Dave Franco
as Pete
Ike Barinholtz
as Jimmy
Lisa Kudrow
as Dean Carol Gladstone
Selena Gomez
as Phi Lamda President
Jerrod Carmichael
as Garf
Carla Gallo
as Paula
Kiersey Clemons
as Beth
Beanie Feldstein
as Nora
