Dr. Frankenstein and her assistant, Dr. Yanco, are going to bring one of their experiments to life in Santo Vs. Frankenstein's Daughter. She intends to use a monster named Ursus to do her evil bidding. Using a youth serum to retain their vitality, the doctors set their sights upon none other than El Santo. They need his super human blood to regenerate a stronger youth serum. They kidnap Santo's goddaughter, Norma and lure him into Dr. Frankenstein's lab where he is captured and enslaved. Will Santo make it out alive?
El Santo
as Santo
Gina Romand
as Dr. Freda Frankenstein
Anel
as o. A.
Roberto Cañedo
as Dr. Yanco
Sonia Fuentes
as Elso
Carlos Agostí
as Don Elias
Carlos Suárez
as Tuerto
Gerardo Zepeda
as Ursus / Truxon
Carlos Bravo y Fernández 'Carlhillos'
as Carcelero
Goliat Ayala
as Luchador
Ismael Ramirez
as Luchador
Enrique Llanes
as Narrator
