Poomukhappadiyil Ninneyum Kathu movie revolves around Dr. Isaac (Mammootty) who has a jealous wife (Srividhya) who constantly suspects him of philandering. When an attractive young woman with a correspondingly jealous husband (Thilakan) moves into the neighboring house, tensions rise. The respective children of the two bickering couples (Rehman and Sisily) start a little romance of their own, which complicates matters further since one family is Hindu, the other Christian, and both sets of parents are opposed to the alliance.
Mammootty
as Dr. Isaac
Srividya
as Issac's wife
Rahman
as
Sisily
as
Thilakan
as
Sulakshana
as
Mohanlal
as Pauly