Rodrigo Borgia, Pope Alexander VI, has three adult children: Juan, who is virtuous and has a sweetheart who is a woman of the people, Lucrezia, who is virtuous and wants to marry Alfonso, and Cesare, who is wicked and lusts after Lucrezia, Juan's girlfriend, and probably others. Cesare has vowed to kill any suitor for Lucrezia's love, and he has three thugs to carry out his wishes. Bodies fall into the Tiber, into the Colosseum (with lions prowling), and onto the Vatican floors.
Conrad Veidt
as Cesare Borgia
Liane Haid
as Lucrezia Borgia (Fandanga)
Albert Bassermann
as Papst Alexander VI Rodrigo Borgia
Paul Wegener
as Micheletto
Heinrich George
as Sebastiano
Adolf E. Licho
as Lodowico
William Dieterle
as Giovanni Sforza, Herr von Pesaro
Lothar Müthel
as Juan Borgia
Alphons Fryland
as Alfonso, Prinz von Arragon
Käte Oswald
as Naomi
Alexander Granach
as ein Gefangener
Anita Berber
as Gräfin Julia Orsini