After their first adventure with the Hot Tub Time Machine, Lou and Nick are living very well off their ill-gotten gains, while Jacob still cannot rely on Lou to be a positive role model. When an unknown assailant breaks into Lou's mansion and shoots him, Nick and Jacob take him for another trip in the hot tub. They emerge in the year 2025, where they must figure out who shot Lou and prevent it from happening again.
Rob Corddry
as Lou Dorchen
Craig Robinson
as Nick Webber
Clark Duke
as Jacob Yates-Dorchen
Bianca Haase
as Sophie
Chevy Chase
as Repairman
Gillian Jacobs
as Jill
Collette Wolfe
as Kelly Yates
Adam Scott
as Adam Yates Stedmeyer Jr.
Kumail Nanjiani
as Brad Syed
Kellee Stewart
as Courtney
Josh Heald
as Terry
Gretchen Koerner
as Susan