Meet Spot, a clever little dog with big dreams of becoming a real boy. When Spot finds out that a crazy scientist can make his wish come true, he takes a cross-country trek with Leonard, his best friend and master, and their mom. However, Dr. Krank's experiments are a little less than perfect, and it will take Leonard and his pet pals to right this genetic wrong.
Nathan Lane
as Spot Helperman / Scott Leadready II / Scott Manly-Manning (voice)
Kelsey Grammer
as Dr. Ivan Krank (voice)
Shaun Fleming
as Leonard Amadeus Helperman (voice)
Debra Jo Rupp
as Mrs. Mary Lou Moira Angela Darling Helperman (voice)
David Ogden Stiers
as Mr. Jolly (voice)
Jerry Stiller
as Pretty Boy (voice)
Paul Reubens
as Dennis (voice)
Megan Mullally
as Adele (voice)
Wallace Shawn
as Principal Crosby Strickler (voice)
Rob Paulsen
as Ian Wazselewski (voice)
Jay Thomas
as Barry Anger (voice)
Estelle Harris
as Mrs. Boogin (voice)
