The film chronicles George's adventures as he befriends Kayla, a baby elephant, at a magic circus show and helps her travel across the country to be reunited with her family.Accompanied by his friend, the Man with the Yellow Hat, George travels by foot, train, and truck to reach Kayla's brother and sister in California, only to be accused of elephant-napping and brought all the way back to New York.
Frank Welker
as George / Duck / Cow (voice)
Amy Hill
as Flower Pot Lady / Irate Woman (voice)
Ed O'Ross
as Ivan the Doorman (voice)
Carlos Alazraqui
as Newspaper Vendor / Conductor (voice)
Jeff Bennett
as Ted (voice)
Fred Tatasciore
as Mr. Bloomsberry (voice)
Nickie Bryar
as Maggie / Teenage Boy (voice)
Jamie Kennedy
as "Danno" Wolfe (voice)
Catherine Taber
as Tina (voice)
Tim Curry
as Piccadilly (voice)
Jeff McNeal
as Kayla / Hog / Tonga / Layla (voice)
Cree Summer
as Ms. Fisher / Cargo Pilot (voice)