After being set-up and betrayed by the man who hired him to assassinate a Texas Senator, an ex-Federale launches a brutal rampage of revenge against his former boss.
Danny Trejo
as Machete
Michelle Rodriguez
as Luz
Jessica Alba
as Sartana Rivera
Robert De Niro
as Senator John McLaughlin
Steven Seagal
as Rogelio Torrez
Cheech Marin
as Padre Cortez
Lindsay Lohan
as April Booth
Electra Avellan
as Nurse Mona
Elise Avellan
as Nurse Lisa
Tom Savini
as Osiris Amanpour
Don Johnson
as Von Jackson
Billy Blair
as Von's Henchman