The story of how a mysterious suitcase brings together, and changes, the lives of a divorced dad, an unhappy housewife, two hitmen, a pair of street thugs, two love struck teens, two FBI men and a psychedelic toad. Based on Pulitzer Prize-winning humorist Dave Barry's best-selling first novel, "Big Trouble."
Tim Allen
as Eliot Arnold
Rene Russo
as Anna Herk
Ben Foster
as Matt Arnold
Jason Lee
as Puggy
Stanley Tucci
as Arthur Herk
Dennis Farina
as Henry Desalvo
Zooey Deschanel
as Jenny Herk
Janeane Garofalo
as Monica Romero
Sofía Vergara
as Nina
Tom Sizemore
as Snake
Johnny Knoxville
as Eddie
Omar Epps
as Seitz
