While carrying on their usual hi-jinks, they inadvertantly stow-away on a spaceship bound for Mars. They meet up with the local Martian residents and cause them to invade the Earth, aided by the "Invincitron", a vacuum-wielding giant robot. Tom, Jerry and their Martian ally, Peep, save the day.
Jeff Bennett
as Dr. Gluckman / Martian Guard #1 / President (voice)
Corey Burton
as Martian Scientist / Court Attendant / Eyes At Gate (voice)
Kathryn Fiore
as Peep / Press Girl (voice)
Brad Garrett
as Commander Bristle / Martian Guard #3 (voice)
Jess Harnell
as Major Buzz Blister / Martian General / Worker #3 (voice)
Tom Kenny
as Grob / Gardener #1 / Martian Guard #2 (voice)
Bill Kopp
as Tom / Press Guy #1 (voice)
Rob Paulsen
as Computer / Worker #1 / Worker #2 (voice)
Frank Welker
as Spike (voice)
Billy West
as Major Biff Buzzard / King Thingg / Gardener #2 (voice)