Adopted as a child, new father Mel Colpin decides he cannot name his son until he knows his birth parents, and determines to make a cross-country quest to find them. Accompanied by his wife, Nancy, and an inept yet gorgeous adoption agent, Tina, he departs on an epic road trip that quickly devolves into a farce of mistaken identities, wrong turns, and overzealous and love-struck ATF agents.
Ben Stiller
as Mel Coplin
Patricia Arquette
as Nancy Coplin
Téa Leoni
as Tina Kalb
Mary Tyler Moore
as Pearl Coplin
George Segal
as Ed Coplin
Alan Alda
as Richard Schlichting
Lily Tomlin
as Mary Schlichting
Richard Jenkins
as Paul Harmon
Josh Brolin
as Tony Kent
Celia Weston
as Valerie Swaney
Glenn Fitzgerald
as Lonnie Schlichting
Beth Stern
as Jane