From an ominous Lecturer, a small 1930s middle American community learns of the Harper Affair, in which young Jimmy Harper finds his life of promise turn into a life of debauchery and murder thanks to the new drug menace marijuana. Along the way, he receives help from his girlfriend Mary and Jesus Himself, but always finds himself in the arms of the Reefer Man and the rest of the denizens of the Reefer Den.
Kristen Bell
as Mary Lane
Christian Campbell
as Jimmy Harper
Neve Campbell
as Miss Poppy
Alan Cumming
as Lecturer / Goat-Man / FDR
Ana Gasteyer
as Mae Coleman
John Kassir
as Ralph Wiley / Uncle Sam
Amy Spanger
as Sally DeBains / Statue of Liberty
Christine Lakin
as Joan of Arc / Female Dancer
Lynda Boyd
as Mrs. Deirdre Greevey
Robert Torti
as Jesus
Steven Weber
as Jack Stone / George Washington
Kevin McNulty
as Mayor Harris MacDonald
