Peter Parker is an outcast high schooler abandoned by his parents as a boy, leaving him to be raised by his Uncle Ben and Aunt May. Like most teenagers, Peter is trying to figure out who he is and how he got to be the person he is today. As Peter discovers a mysterious briefcase that belonged to his father, he begins a quest to understand his parents' disappearance – leading him directly to Oscorp and the lab of Dr. Curt Connors, his father's former partner. As Spider-Man is set on a collision course with Connors' alter ego, The Lizard, Peter will make life-altering choices to use his powers and shape his destiny to become a hero.
Andrew Garfield
as Spider-Man / Peter Parker
Emma Stone
as Gwen Stacy
Rhys Ifans
as The Lizard / Dr. Curt Connors
Denis Leary
as Captain Stacy
Martin Sheen
as Uncle Ben
Sally Field
as Aunt May
Irrfan Khan
as Rajit Ratha
Campbell Scott
as Richard Parker
Embeth Davidtz
as Mary Parker
Chris Zylka
as Flash Thompson
Max Charles
as Peter Parker (Age 4)
C. Thomas Howell
as Jack's Father