Santos, an overweight pacheco fighter suffers from his recent divorce with La Tetona Mendoza, a voluptuous and wild female fighter. To get out of his depression, Santos begins a campaign to help Sahuayo Zombies. However, his philanthropic campaign soon becomes a very profitable business that leverages Santos for their benefit. The population becomes a zombie plague and Santos threatens to dispose of them. However, the Peyote Murderer gets rid of the zombies. But the world without zombies turns out to be worse than anyone could have imagined and the only choice to save the nation is for Santos and Peyote to work together to repopulate the world.
Daniel Giménez Cacho
as Santos (voice)
Héctor Jiménez
as El Cabo (voice)
José María Yázpik
as Peyote Asesino (voice)
Regina Orozco
as La Tetona Mendoza (voice)
Joaquín Cosío
as El Jefe (voice)
Cecilia Suárez
as Kikis Corcuera / La Caperuza (voice)
Irene Azuela
as Rata Maruca / Sirena Lupe (voice)
Jesús Ochoa
as Diablo Zepeda (voice)
Guillermo del Toro
as Gamborimbo Ponx (voice)
Dolores Heredia
as Poquianchis del Espacio (voice)
Julieta Venegas
as Poquianchis 2 (voice)
Rocío Verdejo
as Poquianchis 3 (voice)
