Charlie and Itchy return to Earth to find Gabriel's Horn, but along the way meet up with a young boy named David, who ran away from home.
Charlie Sheen
as Charlie B. Barkin (voice)
Dom DeLuise
as Itchy Itchiford (voice)
Adam Wylie
as David (voice)
Sheena Easton
as Sasha La Fleur (voice)
Ernest Borgnine
as Carface (voice)
George Hearn
as Red (voice)
Bebe Neuwirth
as Anabelle (voice)
Hamilton Camp
as Chihuahua (voice)
Steve Mackall
as Short Customs Dog (voice)
Dan Castellaneta
as Tall Customs Dog / Angel Dog #1 (voice)
Tony Jay
as Reginald (voice)
Jim Cummings
as Jingles (voice)
