Gregory is a devout Catholic who wants to kill evil people in order to grant them safe passage to heaven, Gary is an assembly worker at a trophy shop who wants to kill potential trophy winners, Graham is Gary's intern who will do anything to become a trophy maker and Vinny Van Go drives a road emergency van just to make friends. A coincidental encounter forces these four dim witted rejects to join forces and embark upon an idiotic and altogether hilarious road trip adventure - encountering the likes of skinheads, fraternity jocks, sorority babes, missing children, bikers, porn-stars, clowns, and Kathie Lee Gifford! If the boys aren't careful they might just become human, in what is "the very first serial killer buddy movie of all time
Henry Winkler
as Narrator
Christopher Lloyd
as Dr. Von Gearheart
Beth Behrs
as Brittany
Maria Menounos
as Katelyn
Artie Lange
as Golden Graham
Kathie Lee Gifford
as Herself
Melina Perez
as Devin
David Proval
as Big Chicken
Richard Christy
as Skinhead Leader
Gary Tanguay
as Bike Reporter
Gian Molina
as Vinny
Paul Ashton
as Gregory
