Newly-paroled former US Army ranger Cameron Poe is headed back to his wife, but must fly home aboard a prison transport flight dubbed "Jailbird" taking the “worst of the worst” prisoners, a group described as “pure predators”, to a new super-prison. Poe faces impossible odds when the transport plane is skyjacked mid-flight by the most vicious criminals in the country led by the mastermind — genius serial killer Cyrus "The Virus" Grissom, and backed by black militant Diamond Dog and psychopath Billy Bedlam.
Nicolas Cage
as Cameron Poe
John Cusack
as Agent Vince Larkin
John Malkovich
as Cyrus "The Virus" Grissom
Ving Rhames
as Nathan "Diamond Dog" Jones
Mykelti Williamson
as "Baby-O" O'Dell
Dave Chappelle
as "Pinball" Parker
Colm Meaney
as Agent Duncan Malloy
Monica Potter
as Tricia Poe
Landry Allbright
as Casey Poe
Rachel Ticotin
as Guard Sally Bishop
Steve Buscemi
as Garland Greene - "The Marietta Mangler"
Nick Chinlund
as William "Billy Bedlam" Bedford
