Biography of feuding advice columnist twins, Ann Landers and Abby Van Buren, starts with their early lives in Sioux City, Iowa when they were known as Esther and Pauline through their double wedding and follows them into their columnist successes. However, much of the film also concentrates on their personal and professional feuds that ran the course of their lives. Written by John Sacksteder
Wendie Malick
as Ann Landers / Abigail Van Buren
Robert Desiderio
as Mort
Kip Gilman
as Jules (as Kenneth David Gilman)
Michelle Duffy
as Grown Margo
David Groh
as Abe
Tyler Gannon
as Young Margo
Joann Johnson
as Rebecca
Karen Johnson-Miller
as Beauty parlor woman #1
Angela Nicole Babb
as Beauty parlor woman #2
Raissa Fleming
as Beauty parlor woman #3
Tobias Anderson
as Dean Evans
George Fosgate
as Cardinal Ryan
