A bizarre accident lands Frank Harris in Cool World, a realm of cartoons. Years later, cartoonist Jack Deebs, who's been drawing Cool World, crosses over as well. He sets his lustful sights on animated femme fatale Holli Would, but she's got plans of her own to become real, and it's up to Frank to stop her.
Kim Basinger
as Holli Would
Gabriel Byrne
as Jack Deebs
Brad Pitt
as Detective Frank Harris
Michele Abrams
as Jennifer Malley
Deirdre O'Connell
as Isabelle Malley
Janni Brenn
as Agatha Rose Harris
William Frankfather
as Cop
Greg Collins
as Cop
Maurice LaMarche
as Interrogator #2 / Mash / drunken bar patron / Dr. Vincent "Vegas Vinnie" Whiskers / Jack Deebs (super hero version) (voice)
Michael David Lally
as Sparks (voice)
Carrie Hamilton
as Comic Bookstore Cashier
Stephen Worth
as Bash (performance model) / Comic Store Patron
