While celebrating her 21st birthday, Kara Zor-El travels across the galaxy with her dog Krypto, during which she meets the young Ruthye Marye Knoll and goes on a "murderous quest for revenge".
Milly Alcock
as Kara Zor-El / Supergirl
Jason Momoa
as Lobo
Matthias Schoenaerts
as Krem of the Yellow Hills
Eve Ridley
as Ruthye Mary Knolle
David Krumholtz
as Zor-El
Emily Beecham
as Alura In-Ze
Alice Hewkin
as
