A young woman with no strong religious beliefs, Frankie Paige begins having strange and violent experiences, showing signs of the wounds that Jesus received when crucified. When the Vatican gets word of Frankie's situation, a high-ranking cardinal requests that the Rev. Andrew Kiernan investigate her case. Soon Kiernan realizes that very sinister forces are at work, and tries to rescue Frankie from the entity that is plaguing her.
Patricia Arquette
as Frankie Paige
Gabriel Byrne
as Father Andrew Kiernan
Jonathan Pryce
as Cardinal Daniel Houseman
Nia Long
as Donna Chadway
Thomas Kopache
as Father Durning
Rade Šerbedžija
as Marion Petrocelli
Enrico Colantoni
as Father Dario
Dick Latessa
as Father Gianni Delmonico
Portia de Rossi
as Jennifer Kelliho
Patrick Muldoon
as Steven
Ann Cusack
as Dr. Reston
Shaun Toub
as Doctor
