Romano Orzari
as Giovanni Auditore
Manuel Tadros
as Rodrigo Borgia
Jesse Rath
as Federico Auditore
Devon Bostick
as Ezio Auditore
Alex Ivanovici
as Lorenzo Medici
Michel Perron
as Uberto Alberti
Arthur Grosser
as Pope Sixtus IV
Peter Miller
as Galleazzo Maria Sforza
Harry Standjofski
as Silvio Barbarigo
Frank Fontaine
as Shawn Baichoo
Claudia Ferri
as Maria Auditore
Devery Jacobs
as Claudia Auditore
